Drug interactions
Ceritinib + Doxorubicin
Severity: Moderate
Ceritinib and Doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and P-glycoprotein, which may raise doxorubicin exposure. Higher levels could worsen myelosuppression and cardiotoxicity. Ceritinib itself can prolong the QT interval and cause bradycardia.
What this interaction means in plain words
Ceritinib and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Doxorubicin belongs to Oncology.
Why it happens
Ceritinib inhibition of CYP3A4 and P-gp may reduce doxorubicin clearance.
What to do
Monitor blood counts and cardiac function, including ECG and left ventricular ejection fraction, during combined use. Consider doxorubicin dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Doxorubicin?
MediHelp rates the interaction as moderate. Ceritinib and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and P-glycoprotein, which may raise doxorubicin exposure. Higher levels could worsen myelosuppression and cardiotoxicity. Ceritinib itself can prolong the QT interval and cause bradycardia.
How serious is the interaction between Ceritinib and Doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, including ECG and left ventricular ejection fraction, during combined use. Consider doxorubicin dose reduction if toxicity develops.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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