Drug interactions
Ceritinib + Ethinyl estradiol-levonorgestrel
Severity: Minor
Ceritinib and Ethinyl estradiol-levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise levonorgestrel concentrations. The clinical effect is likely small. Ceritinib may also cause embryo-fetal harm, so reliable contraception is important.
What this interaction means in plain words
Ceritinib and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceritinib belongs to Oncology; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 metabolism of levonorgestrel by ceritinib.
What to do
No dose change is needed. Monitor for progestogenic adverse effects such as breast tenderness and bleeding changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ceritinib and Ethinyl estradiol-levonorgestrel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as minor. Ceritinib and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceritinib inhibits CYP3A4 and may raise levonorgestrel concentrations. The clinical effect is likely small. Ceritinib may also cause embryo-fetal harm, so reliable contraception is important.
How serious is the interaction between Ceritinib and Ethinyl estradiol-levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for progestogenic adverse effects such as breast tenderness and bleeding changes.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
