Drug interactions
Ceritinib + Ethosuximide
Severity: Moderate
Ceritinib and Ethosuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4, and ethosuximide is partly cleared by this enzyme. Ethosuximide exposure may rise, with more dose-related effects such as drowsiness, nausea and ataxia.
What this interaction means in plain words
Ceritinib and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Ethosuximide belongs to Central Nervous System.
Why it happens
Ceritinib inhibits CYP3A4 and reduces the hepatic metabolism of ethosuximide.
What to do
Monitor for ethosuximide adverse effects and check serum levels if toxicity is suspected. Reduce the ethosuximide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Ethosuximide?
MediHelp rates the interaction as moderate. Ceritinib and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4, and ethosuximide is partly cleared by this enzyme. Ethosuximide exposure may rise, with more dose-related effects such as drowsiness, nausea and ataxia.
How serious is the interaction between Ceritinib and Ethosuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ethosuximide adverse effects and check serum levels if toxicity is suspected. Reduce the ethosuximide dose if needed.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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