Drug interactions
Ceritinib + Fluticasone furoate
Severity: Moderate
Ceritinib and Fluticasone furoate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a strong CYP3A4 inhibitor and can increase systemic fluticasone furoate exposure. This raises the risk of systemic corticosteroid effects such as adrenal suppression.
What this interaction means in plain words
Ceritinib and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ceritinib inhibits CYP3A4-mediated fluticasone metabolism.
What to do
Monitor for signs of hypercortisolism and adrenal suppression during long-term use. Consider a less CYP3A4-dependent corticosteroid for prolonged therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Fluticasone furoate?
MediHelp rates the interaction as moderate. Ceritinib and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib is a strong CYP3A4 inhibitor and can increase systemic fluticasone furoate exposure. This raises the risk of systemic corticosteroid effects such as adrenal suppression.
How serious is the interaction between Ceritinib and Fluticasone furoate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of hypercortisolism and adrenal suppression during long-term use. Consider a less CYP3A4-dependent corticosteroid for prolonged therapy.
What other medicines interact with Ceritinib?
MediHelp also lists interactions of Ceritinib with, for example, Cisapride, Eletriptan, Flibanserin. The full list is on the Ceritinib page.
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