Drug interactions
Ceritinib + Ketamine
Severity: Moderate
Ceritinib and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a CYP3A4 inhibitor and ketamine is metabolized partly by CYP3A4 and CYP2B6. Higher ketamine exposure may prolong or intensify sedation, dissociation and cardiovascular effects.
What this interaction means in plain words
Ceritinib and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Ketamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated ketamine N-demethylation by ceritinib.
What to do
Use the lowest effective ketamine dose and monitor sedation, blood pressure and heart rate. Allow extra recovery time after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Ketamine?
MediHelp rates the interaction as moderate. Ceritinib and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib is a CYP3A4 inhibitor and ketamine is metabolized partly by CYP3A4 and CYP2B6. Higher ketamine exposure may prolong or intensify sedation, dissociation and cardiovascular effects.
How serious is the interaction between Ceritinib and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ketamine dose and monitor sedation, blood pressure and heart rate. Allow extra recovery time after dosing.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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