Drug interactions
Ceritinib + Metformin
Severity: Moderate
Ceritinib and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib commonly causes hyperglycemia, which may reduce the effectiveness of metformin in diabetic patients. Glucose control can deteriorate during treatment.
What this interaction means in plain words
Ceritinib and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Metformin belongs to Endocrine.
Why it happens
Ceritinib-associated hyperglycemia pharmacodynamically opposes metformin's glucose-lowering effect.
What to do
Monitor blood glucose regularly during ceritinib therapy and intensify antidiabetic treatment if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Metformin?
MediHelp rates the interaction as moderate. Ceritinib and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib commonly causes hyperglycemia, which may reduce the effectiveness of metformin in diabetic patients. Glucose control can deteriorate during treatment.
How serious is the interaction between Ceritinib and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly during ceritinib therapy and intensify antidiabetic treatment if needed.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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