Drug interactions
Ceritinib + Olanzapine
Severity: Moderate
Ceritinib and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib prolongs the QT interval in a concentration-dependent way, and olanzapine may add a small further effect. Combined use raises arrhythmia risk, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Ceritinib and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Olanzapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization.
What to do
Monitor ECG and electrolytes at baseline and periodically, and correct hypokalemia and hypomagnesemia. Consider an alternative antipsychotic if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Olanzapine?
MediHelp rates the interaction as moderate. Ceritinib and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib prolongs the QT interval in a concentration-dependent way, and olanzapine may add a small further effect. Combined use raises arrhythmia risk, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Ceritinib and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, and correct hypokalemia and hypomagnesemia. Consider an alternative antipsychotic if QTc becomes markedly prolonged.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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