Drug interactions
Ceritinib + Rabeprazole
Severity: Moderate
Ceritinib and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib solubility is pH-dependent, so acid suppression can reduce its absorption. Exposure was lowered with a PPI in studies, which may weaken antitumor effect, though the extent is moderate and may be smaller when taken with food.
What this interaction means in plain words
Ceritinib and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces ceritinib dissolution and absorption.
What to do
Where possible avoid the PPI or use a short-acting antacid or H2 blocker separated from ceritinib. If a PPI is needed, monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Rabeprazole?
MediHelp rates the interaction as moderate. Ceritinib and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib solubility is pH-dependent, so acid suppression can reduce its absorption. Exposure was lowered with a PPI in studies, which may weaken antitumor effect, though the extent is moderate and may be smaller when taken with food.
How serious is the interaction between Ceritinib and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible avoid the PPI or use a short-acting antacid or H2 blocker separated from ceritinib. If a PPI is needed, monitor tumor response.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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