Drug interactions
Ceritinib + Ulipristal
Severity: Moderate
Ceritinib and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise ulipristal levels, while ulipristal may inhibit P-glycoprotein and modestly raise ceritinib levels. Increased exposure to either drug could increase adverse effects, such as QT prolongation or GI toxicity with ceritinib.
What this interaction means in plain words
Ceritinib and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ceritinib inhibits CYP3A4 metabolism of ulipristal, and ulipristal may inhibit P-gp efflux of ceritinib.
What to do
Consider an alternative emergency contraceptive such as a copper IUD. If ulipristal is used, monitor for ceritinib adverse effects including GI symptoms and QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Ulipristal?
MediHelp rates the interaction as moderate. Ceritinib and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise ulipristal levels, while ulipristal may inhibit P-glycoprotein and modestly raise ceritinib levels. Increased exposure to either drug could increase adverse effects, such as QT prolongation or GI toxicity with ceritinib.
How serious is the interaction between Ceritinib and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative emergency contraceptive such as a copper IUD. If ulipristal is used, monitor for ceritinib adverse effects including GI symptoms and QT prolongation.
What other medicines interact with Ceritinib?
MediHelp also lists interactions of Ceritinib with, for example, Cisapride, Eletriptan, Flibanserin. The full list is on the Ceritinib page.
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