Drug interactions
Ceritinib + Venlafaxine
Severity: Moderate
Ceritinib and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and CYP2C9 and can prolong the QT interval. Venlafaxine is mainly cleared by CYP2D6, with a minor CYP3A4 contribution, so exposure changes are modest, but the additive QT effect is the greater concern.
What this interaction means in plain words
Ceritinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Minor CYP3A4 inhibition raising venlafaxine levels, plus possible additive QT prolongation.
What to do
Monitor ECG and electrolytes during coadministration and watch for venlafaxine adverse effects such as hypertension and nausea. Reduce the venlafaxine dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Venlafaxine?
MediHelp rates the interaction as moderate. Ceritinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and CYP2C9 and can prolong the QT interval. Venlafaxine is mainly cleared by CYP2D6, with a minor CYP3A4 contribution, so exposure changes are modest, but the additive QT effect is the greater concern.
How serious is the interaction between Ceritinib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes during coadministration and watch for venlafaxine adverse effects such as hypertension and nausea. Reduce the venlafaxine dose if these occur.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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