Drug interactions
Ceritinib + Zolpidem
Severity: Moderate
Ceritinib and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a CYP3A4 inhibitor and may raise zolpidem concentrations, which could prolong sedation and increase next-day impairment. The effect is likely modest because zolpidem has several metabolic pathways.
What this interaction means in plain words
Ceritinib and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Zolpidem belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated zolpidem metabolism by ceritinib.
What to do
Consider a lower starting zolpidem dose and monitor for excess sedation and psychomotor impairment. Counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Zolpidem?
MediHelp rates the interaction as moderate. Ceritinib and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib is a CYP3A4 inhibitor and may raise zolpidem concentrations, which could prolong sedation and increase next-day impairment. The effect is likely modest because zolpidem has several metabolic pathways.
How serious is the interaction between Ceritinib and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower starting zolpidem dose and monitor for excess sedation and psychomotor impairment. Counsel on driving.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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