Drug interactions
Certolizumab pegol + Pneumococcal vaccine 13-valent
Severity: Minor
Certolizumab pegol and Pneumococcal vaccine 13-valent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
TNF inhibitors can reduce antibody responses to pneumococcal vaccination. The vaccine is not live and can be given, but protection may be diminished.
What this interaction means in plain words
Certolizumab pegol and Pneumococcal vaccine 13-valent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Certolizumab pegol belongs to Musculoskeletal; Pneumococcal vaccine 13-valent belongs to Miscellaneous.
Why it happens
TNF blockade-related immunosuppression may blunt vaccine-induced antibody production.
What to do
Vaccinate ideally before starting certolizumab, and do not withhold the vaccine in treated patients. Consider checking titres in high-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Certolizumab pegol with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as minor. Certolizumab pegol and Pneumococcal vaccine 13-valent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. TNF inhibitors can reduce antibody responses to pneumococcal vaccination. The vaccine is not live and can be given, but protection may be diminished.
How serious is the interaction between Certolizumab pegol and Pneumococcal vaccine 13-valent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally before starting certolizumab, and do not withhold the vaccine in treated patients. Consider checking titres in high-risk patients.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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