Drug interactions
Cetirizine + Midazolam intranasal
Severity: Minor
Cetirizine and Midazolam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal midazolam causes sedation and can cause respiratory depression, and other agents that cause drowsiness may deepen or prolong this effect. Cetirizine has mild sedative properties, so the added effect is usually small.
What this interaction means in plain words
Cetirizine and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Monitor sedation level and oxygen saturation after midazolam dosing. Avoid combining with additional sedatives where possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Frequently asked questions
Can I take Cetirizine with Midazolam intranasal?
MediHelp rates the interaction as minor. Cetirizine and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intranasal midazolam causes sedation and can cause respiratory depression, and other agents that cause drowsiness may deepen or prolong this effect. Cetirizine has mild sedative properties, so the added effect is usually small.
How serious is the interaction between Cetirizine and Midazolam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and oxygen saturation after midazolam dosing. Avoid combining with additional sedatives where possible.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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