Drug interactions
Brexpiprazole + Cetirizine
Severity: Moderate
Brexpiprazole and Cetirizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole commonly causes somnolence and cetirizine can add to drowsiness. The combination may impair alertness and psychomotor function.
What this interaction means in plain words
Brexpiprazole and Cetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Cetirizine belongs to Respiratory.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excess sedation and advise caution with driving; use a non-sedating antihistamine alternative if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brivaracetam + Cetirizine Moderate
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Cetirizine?
MediHelp rates the interaction as moderate. Brexpiprazole and Cetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole commonly causes somnolence and cetirizine can add to drowsiness. The combination may impair alertness and psychomotor function.
How serious is the interaction between Brexpiprazole and Cetirizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and advise caution with driving; use a non-sedating antihistamine alternative if drowsiness is troublesome.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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