Drug interactions
Cevimeline + Clomipramine
Severity: Moderate
Cevimeline and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist and clomipramine has strong antimuscarinic effects, so they may oppose each other. Cevimeline may be less effective at relieving dry mouth, and clomipramine can itself cause dry mouth.
What this interaction means in plain words
Cevimeline and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Clomipramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced saliva response to cevimeline. Consider a less anticholinergic antidepressant if dry mouth control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Clomipramine?
MediHelp rates the interaction as moderate. Cevimeline and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist and clomipramine has strong antimuscarinic effects, so they may oppose each other. Cevimeline may be less effective at relieving dry mouth, and clomipramine can itself cause dry mouth.
How serious is the interaction between Cevimeline and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced saliva response to cevimeline. Consider a less anticholinergic antidepressant if dry mouth control is inadequate.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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