Drug interactions
Cevimeline + Dasatinib
Severity: Minor
Cevimeline and Dasatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is metabolized by CYP3A4 and CYP2D6, and dasatinib may modestly raise its levels. This could increase cholinergic effects such as sweating, nausea and bradycardia.
What this interaction means in plain words
Cevimeline and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cevimeline belongs to Miscellaneous; Dasatinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by dasatinib slows cevimeline metabolism.
What to do
Monitor for cholinergic adverse effects such as sweating, nausea and slow heart rate. Reduce the cevimeline dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Dasatinib?
MediHelp rates the interaction as minor. Cevimeline and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cevimeline is metabolized by CYP3A4 and CYP2D6, and dasatinib may modestly raise its levels. This could increase cholinergic effects such as sweating, nausea and bradycardia.
How serious is the interaction between Cevimeline and Dasatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects such as sweating, nausea and slow heart rate. Reduce the cevimeline dose if they occur.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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