Drug interactions
Cevimeline + Dronedarone
Severity: Moderate
Cevimeline and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may raise cevimeline levels through CYP3A4 inhibition. Cevimeline's cholinergic effects, such as sweating, nausea and bradycardia, may be increased, and bradycardia is additive with dronedarone.
What this interaction means in plain words
Cevimeline and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Dronedarone belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism of cevimeline.
What to do
Monitor heart rate and cholinergic adverse effects. Reduce the cevimeline dose if bradycardia or intolerance occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Dronedarone?
MediHelp rates the interaction as moderate. Cevimeline and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may raise cevimeline levels through CYP3A4 inhibition. Cevimeline's cholinergic effects, such as sweating, nausea and bradycardia, may be increased, and bradycardia is additive with dronedarone.
How serious is the interaction between Cevimeline and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and cholinergic adverse effects. Reduce the cevimeline dose if bradycardia or intolerance occurs.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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