Drug interactions
Cevimeline + Esmolol
Severity: Moderate
Cevimeline and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist that can cause bradycardia and conduction disturbances. Beta-blockers may add to conduction effects, and cevimeline's labeling warns of possible conduction disturbances with beta-blockers.
What this interaction means in plain words
Cevimeline and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Esmolol belongs to Cardiovascular.
Why it happens
Additive effects on cardiac conduction from cholinergic stimulation and beta-blockade.
What to do
Monitor heart rate and ECG in patients with cardiac disease; avoid in those with uncontrolled arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Esmolol?
MediHelp rates the interaction as moderate. Cevimeline and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist that can cause bradycardia and conduction disturbances. Beta-blockers may add to conduction effects, and cevimeline's labeling warns of possible conduction disturbances with beta-blockers.
How serious is the interaction between Cevimeline and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with cardiac disease; avoid in those with uncontrolled arrhythmia.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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