Drug interactions
Cevimeline + Indacaterol-glycopyrronium
Severity: Moderate
Cevimeline and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist and glycopyrronium is a muscarinic antagonist, so they may oppose each other. Cevimeline may be less effective for dry mouth, and cholinergic effects may be blunted.
What this interaction means in plain words
Cevimeline and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced salivary response to cevimeline. Review the need for the anticholinergic if dry mouth control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Cevimeline and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist and glycopyrronium is a muscarinic antagonist, so they may oppose each other. Cevimeline may be less effective for dry mouth, and cholinergic effects may be blunted.
How serious is the interaction between Cevimeline and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced salivary response to cevimeline. Review the need for the anticholinergic if dry mouth control is lost.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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