Drug interactions
Clozapine + Ipratropium
Severity: Moderate
Clozapine and Ipratropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine has marked anticholinergic activity, and ipratropium may add to the risk of constipation, urinary retention and tachycardia. Clozapine-related constipation can progress to serious gastrointestinal hypomotility, so extra anticholinergic load is relevant.
What this interaction means in plain words
Clozapine and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Ipratropium belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor bowel function closely and ask the patient about constipation regularly. Consider a laxative and reassess the need for additional anticholinergic drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clozapine and Ipratropium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Ipratropium?
MediHelp rates the interaction as moderate. Clozapine and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine has marked anticholinergic activity, and ipratropium may add to the risk of constipation, urinary retention and tachycardia. Clozapine-related constipation can progress to serious gastrointestinal hypomotility, so extra anticholinergic load is relevant.
How serious is the interaction between Clozapine and Ipratropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function closely and ask the patient about constipation regularly. Consider a laxative and reassess the need for additional anticholinergic drugs.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
