Drug interactions
Cevimeline + Itraconazole
Severity: Moderate
Cevimeline and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is metabolized by CYP2D6 and CYP3A4, and itraconazole may raise its levels. This may increase cholinergic effects such as sweating, nausea, diarrhea and bradycardia.
What this interaction means in plain words
Cevimeline and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Itraconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by itraconazole decreases cevimeline metabolism.
What to do
Monitor for cholinergic adverse effects and heart rate, especially in patients who are also CYP2D6 poor metabolizers or taking CYP2D6 inhibitors. Lower the cevimeline dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Itraconazole?
MediHelp rates the interaction as moderate. Cevimeline and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is metabolized by CYP2D6 and CYP3A4, and itraconazole may raise its levels. This may increase cholinergic effects such as sweating, nausea, diarrhea and bradycardia.
How serious is the interaction between Cevimeline and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects and heart rate, especially in patients who are also CYP2D6 poor metabolizers or taking CYP2D6 inhibitors. Lower the cevimeline dose if symptoms occur.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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