Drug interactions
Cevimeline + Labetalol
Severity: Moderate
Cevimeline and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist that can cause bradycardia and conduction disturbances, and beta blockers may add to these effects. Cases of heart rhythm problems are possible in susceptible patients, and cevimeline labeling advises caution with beta blockers.
What this interaction means in plain words
Cevimeline and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Labetalol belongs to Cardiovascular.
Why it happens
Additive effects on cardiac conduction from cholinergic stimulation and beta-adrenergic blockade.
What to do
Monitor heart rate and ECG in patients with conduction disease or bradycardia. Avoid the combination in patients with uncontrolled asthma or significant cardiac conduction abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Labetalol?
MediHelp rates the interaction as moderate. Cevimeline and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist that can cause bradycardia and conduction disturbances, and beta blockers may add to these effects. Cases of heart rhythm problems are possible in susceptible patients, and cevimeline labeling advises caution with beta blockers.
How serious is the interaction between Cevimeline and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with conduction disease or bradycardia. Avoid the combination in patients with uncontrolled asthma or significant cardiac conduction abnormalities.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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