Drug interactions
Cevimeline + Succinylcholine
Severity: Moderate
Cevimeline and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist, and succinylcholine is a depolarizing neuromuscular blocker. Cevimeline may add to cholinergic effects such as bradycardia, and it could modify the neuromuscular blockade. Clinical data are scarce.
What this interaction means in plain words
Cevimeline and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Succinylcholine belongs to Musculoskeletal.
Why it happens
Additive cholinergic stimulation; cevimeline is a muscarinic agonist and succinylcholine a nicotinic agonist.
What to do
Tell the anesthesia team about cevimeline use before surgery. Monitor heart rate and neuromuscular function, and have an antimuscarinic such as atropine available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Succinylcholine
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Succinylcholine?
MediHelp rates the interaction as moderate. Cevimeline and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist, and succinylcholine is a depolarizing neuromuscular blocker. Cevimeline may add to cholinergic effects such as bradycardia, and it could modify the neuromuscular blockade. Clinical data are scarce.
How serious is the interaction between Cevimeline and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about cevimeline use before surgery. Monitor heart rate and neuromuscular function, and have an antimuscarinic such as atropine available.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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