Drug interactions
Cevimeline + Voriconazole
Severity: Moderate
Cevimeline and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is metabolized by CYP2D6 and CYP3A4, so voriconazole may raise its levels. This could increase cholinergic effects such as sweating, nausea, diarrhea and bradycardia.
What this interaction means in plain words
Cevimeline and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by voriconazole reduces cevimeline metabolism.
What to do
Monitor for cholinergic adverse effects, especially in patients with cardiac conduction problems, and reduce the cevimeline dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Voriconazole?
MediHelp rates the interaction as moderate. Cevimeline and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is metabolized by CYP2D6 and CYP3A4, so voriconazole may raise its levels. This could increase cholinergic effects such as sweating, nausea, diarrhea and bradycardia.
How serious is the interaction between Cevimeline and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects, especially in patients with cardiac conduction problems, and reduce the cevimeline dose if they occur.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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