Drug interactions
Chloral hydrate + Daridorexant
Severity: Moderate
Chloral hydrate and Daridorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote sleep and depress the central nervous system. Taken together they can cause excessive sedation, impaired psychomotor performance and next-day impairment of alertness and driving ability.
What this interaction means in plain words
Chloral hydrate and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Daridorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from sedative-hypnotic GABAergic activity and orexin receptor antagonism.
What to do
Avoid concurrent hypnotics where possible; if both are needed, use the lowest daridorexant dose and monitor for daytime sedation. Advise patients to avoid driving or hazardous tasks if impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Chloral hydrate with Daridorexant?
MediHelp rates the interaction as moderate. Chloral hydrate and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote sleep and depress the central nervous system. Taken together they can cause excessive sedation, impaired psychomotor performance and next-day impairment of alertness and driving ability.
How serious is the interaction between Chloral hydrate and Daridorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent hypnotics where possible; if both are needed, use the lowest daridorexant dose and monitor for daytime sedation. Advise patients to avoid driving or hazardous tasks if impaired.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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