Drug interactions
Chloral hydrate + Dexmedetomidine
Severity: Moderate
Chloral hydrate and Dexmedetomidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine is a sedative alpha-2 agonist whose effects add to those of chloral hydrate. Combined use can deepen sedation and cause bradycardia and hypotension.
What this interaction means in plain words
Chloral hydrate and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Dexmedetomidine belongs to Central Nervous System.
Why it happens
Additive CNS depression plus alpha-2 mediated hemodynamic effects.
What to do
Monitor sedation depth, heart rate, blood pressure and respiration, and reduce doses of either drug as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Chloral hydrate with Dexmedetomidine?
MediHelp rates the interaction as moderate. Chloral hydrate and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine is a sedative alpha-2 agonist whose effects add to those of chloral hydrate. Combined use can deepen sedation and cause bradycardia and hypotension.
How serious is the interaction between Chloral hydrate and Dexmedetomidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation depth, heart rate, blood pressure and respiration, and reduce doses of either drug as needed.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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