Drug interactions
Chloral hydrate + Haloperidol
Severity: Moderate
Chloral hydrate and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol and chloral hydrate both cause sedation, so concurrent use may lead to oversedation and psychomotor impairment. Risk is greater in older adults and with higher doses.
What this interaction means in plain words
Chloral hydrate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive CNS depression from a sedative-hypnotic and an antipsychotic.
What to do
Monitor level of sedation and respiratory status, and use the lowest effective doses. Avoid alcohol and other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Chloral hydrate with Haloperidol?
MediHelp rates the interaction as moderate. Chloral hydrate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol and chloral hydrate both cause sedation, so concurrent use may lead to oversedation and psychomotor impairment. Risk is greater in older adults and with higher doses.
How serious is the interaction between Chloral hydrate and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of sedation and respiratory status, and use the lowest effective doses. Avoid alcohol and other CNS depressants.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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