Drug interactions
Chloral hydrate + Iloperidone
Severity: Moderate
Chloral hydrate and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an atypical antipsychotic that causes somnolence, orthostatic hypotension and QT prolongation. With chloral hydrate, sedation and hypotension may be increased, raising the risk of falls.
What this interaction means in plain words
Chloral hydrate and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and alpha-1 adrenergic blockade related hypotension, with iloperidone QT effects.
What to do
Monitor sedation and orthostatic blood pressure, and use lower doses in older patients. Check ECG if other QT-prolonging risks exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Chloral hydrate with Iloperidone?
MediHelp rates the interaction as moderate. Chloral hydrate and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is an atypical antipsychotic that causes somnolence, orthostatic hypotension and QT prolongation. With chloral hydrate, sedation and hypotension may be increased, raising the risk of falls.
How serious is the interaction between Chloral hydrate and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, and use lower doses in older patients. Check ECG if other QT-prolonging risks exist.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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