Drug interactions
Chloral hydrate + Nabilone
Severity: Moderate
Chloral hydrate and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate is a sedative-hypnotic and nabilone adds central depressant effects. Together they may cause deep sedation, confusion and impaired psychomotor function.
What this interaction means in plain words
Chloral hydrate and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression through pharmacodynamic synergy.
What to do
Use reduced doses and monitor level of consciousness, especially in older patients. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Nabilone?
MediHelp rates the interaction as moderate. Chloral hydrate and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloral hydrate is a sedative-hypnotic and nabilone adds central depressant effects. Together they may cause deep sedation, confusion and impaired psychomotor function.
How serious is the interaction between Chloral hydrate and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced doses and monitor level of consciousness, especially in older patients. Avoid alcohol and other sedatives.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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