Drug interactions
Chloral hydrate + Paliperidone
Severity: Moderate
Chloral hydrate and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can cause somnolence and orthostatic hypotension, which may add to the sedative effects of chloral hydrate. The result is usually increased drowsiness that is manageable with monitoring.
What this interaction means in plain words
Chloral hydrate and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from a sedative-hypnotic and an atypical antipsychotic.
What to do
Monitor for excessive sedation and hypotension, and reduce the hypnotic dose if needed. Counsel patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Chloral hydrate with Paliperidone?
MediHelp rates the interaction as moderate. Chloral hydrate and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can cause somnolence and orthostatic hypotension, which may add to the sedative effects of chloral hydrate. The result is usually increased drowsiness that is manageable with monitoring.
How serious is the interaction between Chloral hydrate and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and hypotension, and reduce the hypnotic dose if needed. Counsel patients about driving and alcohol.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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