Drug interactions
Chlorambucil + Cisplatin
Severity: Moderate
Chlorambucil and Cisplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have myelosuppressive effects, and cisplatin adds nephrotoxicity, ototoxicity and neurotoxicity. Together they increase the risk of cytopenias and infection.
What this interaction means in plain words
Chlorambucil and Cisplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorambucil belongs to Oncology; Cisplatin belongs to Oncology.
Why it happens
Additive myelosuppression from two cytotoxic agents.
What to do
Monitor complete blood counts and renal function, and adjust doses or delay cycles based on counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorambucil
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Chlorambucil with Cisplatin?
MediHelp rates the interaction as moderate. Chlorambucil and Cisplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have myelosuppressive effects, and cisplatin adds nephrotoxicity, ototoxicity and neurotoxicity. Together they increase the risk of cytopenias and infection.
How serious is the interaction between Chlorambucil and Cisplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function, and adjust doses or delay cycles based on counts.
What other medicines interact with Chlorambucil?
MediHelp also lists interactions of Chlorambucil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Chlorambucil page.
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