Drug interactions
Chlorambucil + Oxaliplatin
Severity: Moderate
Chlorambucil and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorambucil and oxaliplatin both can depress bone marrow function. Concurrent use may increase the frequency and severity of neutropenia and thrombocytopenia, with higher infection and bleeding risk.
What this interaction means in plain words
Chlorambucil and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorambucil belongs to Oncology; Oxaliplatin belongs to Oncology.
Why it happens
Additive myelosuppressive effects of an alkylating agent and a platinum cytotoxic.
What to do
Check complete blood counts before each cycle and at the expected nadir, and adjust doses or delay treatment for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorambucil
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Chlorambucil with Oxaliplatin?
MediHelp rates the interaction as moderate. Chlorambucil and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorambucil and oxaliplatin both can depress bone marrow function. Concurrent use may increase the frequency and severity of neutropenia and thrombocytopenia, with higher infection and bleeding risk.
How serious is the interaction between Chlorambucil and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check complete blood counts before each cycle and at the expected nadir, and adjust doses or delay treatment for significant cytopenias.
What other medicines interact with Chlorambucil?
MediHelp also lists interactions of Chlorambucil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Chlorambucil page.
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