Drug interactions
Chlorambucil + Trastuzumab deruxtecan
Severity: Moderate
Chlorambucil and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can cause neutropenia, and combination may raise the risk of febrile neutropenia and infection. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
What this interaction means in plain words
Chlorambucil and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorambucil belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression and immunosuppression.
What to do
Monitor neutrophil counts and signs of infection, and consider dose delay or growth factor support for severe neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorambucil
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Chlorambucil with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Chlorambucil and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can cause neutropenia, and combination may raise the risk of febrile neutropenia and infection. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
How serious is the interaction between Chlorambucil and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of infection, and consider dose delay or growth factor support for severe neutropenia.
What other medicines interact with Chlorambucil?
MediHelp also lists interactions of Chlorambucil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Chlorambucil page.
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