Drug interactions
Chloramphenicol + Cobicistat
Severity: Minor
Chloramphenicol and Cobicistat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is metabolized partly by CYP3A4 and chloramphenicol may raise its levels. The significance is uncertain, but it could increase the boosting effect on other drugs.
What this interaction means in plain words
Chloramphenicol and Cobicistat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloramphenicol belongs to Anti Bacterial; Cobicistat belongs to Miscellaneous.
Why it happens
Possible inhibition of CYP3A4 metabolism of cobicistat.
What to do
No routine change is needed. Monitor for adverse effects of the boosted antiretroviral regimen and check blood counts given chloramphenicol toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloramphenicol
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Cobicistat?
MediHelp rates the interaction as minor. Chloramphenicol and Cobicistat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat is metabolized partly by CYP3A4 and chloramphenicol may raise its levels. The significance is uncertain, but it could increase the boosting effect on other drugs.
How serious is the interaction between Chloramphenicol and Cobicistat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for adverse effects of the boosted antiretroviral regimen and check blood counts given chloramphenicol toxicity.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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