Drug interactions
Chloramphenicol + Daclatasvir
Severity: Moderate
Chloramphenicol and Daclatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may raise daclatasvir exposure because daclatasvir is cleared mainly by CYP3A4. Higher levels could increase adverse effects, although chloramphenicol is a weaker inhibitor than agents such as clarithromycin or azole antifungals.
What this interaction means in plain words
Chloramphenicol and Daclatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Daclatasvir belongs to Anti Virals.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing the metabolism of daclatasvir.
What to do
Monitor for daclatasvir adverse effects such as headache, fatigue and bradycardia if given with amiodarone or sofosbuvir. Prefer a non-interacting antibiotic where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Daclatasvir
Frequently asked questions
Can I take Chloramphenicol with Daclatasvir?
MediHelp rates the interaction as moderate. Chloramphenicol and Daclatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may raise daclatasvir exposure because daclatasvir is cleared mainly by CYP3A4. Higher levels could increase adverse effects, although chloramphenicol is a weaker inhibitor than agents such as clarithromycin or azole antifungals.
How serious is the interaction between Chloramphenicol and Daclatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daclatasvir adverse effects such as headache, fatigue and bradycardia if given with amiodarone or sofosbuvir. Prefer a non-interacting antibiotic where feasible.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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