Drug interactions
Daclatasvir + Mifepristone
Severity: Minor
Daclatasvir and Mifepristone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, a CYP3A4 inhibitor, may increase daclatasvir concentrations. Daclatasvir has a wide therapeutic margin, so the effect is usually modest.
What this interaction means in plain words
Daclatasvir and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Daclatasvir belongs to Anti Virals; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone reduces daclatasvir clearance.
What to do
No routine dose change; monitor for adverse effects such as headache, fatigue and bradycardia, especially if combined with amiodarone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Daclatasvir
Frequently asked questions
Can I take Daclatasvir with Mifepristone?
MediHelp rates the interaction as minor. Daclatasvir and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone, a CYP3A4 inhibitor, may increase daclatasvir concentrations. Daclatasvir has a wide therapeutic margin, so the effect is usually modest.
How serious is the interaction between Daclatasvir and Mifepristone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for adverse effects such as headache, fatigue and bradycardia, especially if combined with amiodarone.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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