Drug interactions
Daclatasvir + Ethinyl estradiol-drospirenone
Severity: Minor
Daclatasvir and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daclatasvir is a CYP3A4 substrate, but drospirenone is not a relevant inhibitor, so no meaningful change in exposure is expected. Daclatasvir has not been shown to compromise combined contraceptive efficacy.
What this interaction means in plain words
Daclatasvir and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Daclatasvir belongs to Anti Virals; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Theoretical weak CYP3A4 inhibition; not clinically established.
What to do
No adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Daclatasvir
- Daclatasvir + Lorlatinib Major
- Chloramphenicol + Daclatasvir Moderate
- Daclatasvir + Ribociclib Moderate
- Daclatasvir + Mifepristone Minor
Frequently asked questions
Can I take Daclatasvir with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Daclatasvir and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Daclatasvir is a CYP3A4 substrate, but drospirenone is not a relevant inhibitor, so no meaningful change in exposure is expected. Daclatasvir has not been shown to compromise combined contraceptive efficacy.
How serious is the interaction between Daclatasvir and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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