Drug interactions
Chloramphenicol + Elacestrant
Severity: Moderate
Chloramphenicol and Elacestrant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elacestrant is metabolized mainly by CYP3A4, and inhibitors can increase its exposure and adverse effects such as nausea, dyslipidemia and hepatic effects.
What this interaction means in plain words
Chloramphenicol and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Elacestrant belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of elacestrant.
What to do
Prefer a different antibiotic. If combined, monitor for elacestrant adverse effects including liver tests and lipids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Elacestrant
Frequently asked questions
Can I take Chloramphenicol with Elacestrant?
MediHelp rates the interaction as moderate. Chloramphenicol and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elacestrant is metabolized mainly by CYP3A4, and inhibitors can increase its exposure and adverse effects such as nausea, dyslipidemia and hepatic effects.
How serious is the interaction between Chloramphenicol and Elacestrant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a different antibiotic. If combined, monitor for elacestrant adverse effects including liver tests and lipids.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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