Drug interactions
Chloramphenicol + Eszopiclone
Severity: Moderate
Chloramphenicol and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eszopiclone is metabolized by CYP3A4, so inhibition may increase exposure and next-day sedation or psychomotor impairment.
What this interaction means in plain words
Chloramphenicol and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Eszopiclone belongs to Central Nervous System.
Why it happens
Chloramphenicol inhibits CYP3A4, decreasing eszopiclone clearance.
What to do
Start with a lower eszopiclone dose and counsel on drowsiness and impaired driving. Reduce the dose if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Eszopiclone
Frequently asked questions
Can I take Chloramphenicol with Eszopiclone?
MediHelp rates the interaction as moderate. Chloramphenicol and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eszopiclone is metabolized by CYP3A4, so inhibition may increase exposure and next-day sedation or psychomotor impairment.
How serious is the interaction between Chloramphenicol and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower eszopiclone dose and counsel on drowsiness and impaired driving. Reduce the dose if sedation is excessive.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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