Drug interactions
Chloramphenicol + Fluticasone-vilanterol
Severity: Minor
Chloramphenicol and Fluticasone-vilanterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol is not a clinically strong CYP3A4 inhibitor, although it has been reported to inhibit CYP3A4 to some degree. A meaningful rise in fluticasone furoate or vilanterol exposure is possible but poorly documented.
What this interaction means in plain words
Chloramphenicol and Fluticasone-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloramphenicol belongs to Anti Bacterial; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Possible weak CYP3A4 inhibition reducing metabolism of fluticasone furoate and vilanterol.
What to do
No routine adjustment is needed. Watch for beta-agonist effects such as tremor and tachycardia, or corticosteroid systemic effects, during prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Fluticasone-vilanterol?
MediHelp rates the interaction as minor. Chloramphenicol and Fluticasone-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol is not a clinically strong CYP3A4 inhibitor, although it has been reported to inhibit CYP3A4 to some degree. A meaningful rise in fluticasone furoate or vilanterol exposure is possible but poorly documented.
How serious is the interaction between Chloramphenicol and Fluticasone-vilanterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for beta-agonist effects such as tremor and tachycardia, or corticosteroid systemic effects, during prolonged use.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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