Drug interactions
Chloramphenicol + Fluticasone
Severity: Moderate
Chloramphenicol and Fluticasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol can inhibit CYP3A4 and may reduce the clearance of fluticasone. Higher systemic fluticasone levels could cause corticosteroid effects such as adrenal suppression, although the clinical data are limited.
What this interaction means in plain words
Chloramphenicol and Fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Fluticasone belongs to Respiratory.
Why it happens
Inhibition of CYP3A4 by chloramphenicol reduces fluticasone metabolism.
What to do
Monitor for signs of systemic corticosteroid excess during prolonged coadministration. Use the lowest effective fluticasone dose or choose a less CYP3A4-dependent corticosteroid if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Fluticasone?
MediHelp rates the interaction as moderate. Chloramphenicol and Fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol can inhibit CYP3A4 and may reduce the clearance of fluticasone. Higher systemic fluticasone levels could cause corticosteroid effects such as adrenal suppression, although the clinical data are limited.
How serious is the interaction between Chloramphenicol and Fluticasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of systemic corticosteroid excess during prolonged coadministration. Use the lowest effective fluticasone dose or choose a less CYP3A4-dependent corticosteroid if needed.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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