Drug interactions
Chloramphenicol + Isavuconazonium
Severity: Moderate
Chloramphenicol and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazonium is converted to isavuconazole, a CYP3A4 substrate, so chloramphenicol may increase its levels. The effect is expected to be less than with strong inhibitors such as ketoconazole, and isavuconazole is not contraindicated with chloramphenicol.
What this interaction means in plain words
Chloramphenicol and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Isavuconazonium belongs to Anti Fungals.
Why it happens
Possible CYP3A4 inhibition by chloramphenicol reduces isavuconazole clearance.
What to do
Monitor for isavuconazole adverse effects such as liver enzyme elevation and QT shortening; consider therapeutic drug monitoring where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Isavuconazonium?
MediHelp rates the interaction as moderate. Chloramphenicol and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazonium is converted to isavuconazole, a CYP3A4 substrate, so chloramphenicol may increase its levels. The effect is expected to be less than with strong inhibitors such as ketoconazole, and isavuconazole is not contraindicated with chloramphenicol.
How serious is the interaction between Chloramphenicol and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for isavuconazole adverse effects such as liver enzyme elevation and QT shortening; consider therapeutic drug monitoring where available.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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