Drug interactions
Chloramphenicol + Leniolisib
Severity: Moderate
Chloramphenicol and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib is cleared mainly by CYP3A4, so inhibition may raise its exposure. This could increase adverse effects such as infections, headache and hematologic or hepatic changes.
What this interaction means in plain words
Chloramphenicol and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Leniolisib belongs to Miscellaneous.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing leniolisib metabolism.
What to do
Consider an alternative antibiotic. If coadministered, monitor for leniolisib adverse effects and liver tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Leniolisib
Frequently asked questions
Can I take Chloramphenicol with Leniolisib?
MediHelp rates the interaction as moderate. Chloramphenicol and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib is cleared mainly by CYP3A4, so inhibition may raise its exposure. This could increase adverse effects such as infections, headache and hematologic or hepatic changes.
How serious is the interaction between Chloramphenicol and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic. If coadministered, monitor for leniolisib adverse effects and liver tests.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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