Drug interactions
Chloramphenicol + Mifepristone
Severity: Moderate
Chloramphenicol and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is metabolized by CYP3A4, so inhibition may increase exposure. Greater exposure is important with chronic high-dose use for Cushing's syndrome, where it can cause hypokalemia and QT prolongation.
What this interaction means in plain words
Chloramphenicol and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Mifepristone belongs to Endocrine.
Why it happens
Chloramphenicol inhibits CYP3A4, decreasing mifepristone clearance.
What to do
With chronic mifepristone therapy, monitor potassium and ECG and limit the dose. Single-dose obstetric use usually needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chloramphenicol and Mifepristone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chloramphenicol
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Mifepristone?
MediHelp rates the interaction as moderate. Chloramphenicol and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone is metabolized by CYP3A4, so inhibition may increase exposure. Greater exposure is important with chronic high-dose use for Cushing's syndrome, where it can cause hypokalemia and QT prolongation.
How serious is the interaction between Chloramphenicol and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With chronic mifepristone therapy, monitor potassium and ECG and limit the dose. Single-dose obstetric use usually needs no change.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
