Drug interactions
Chloramphenicol + Naldemedine
Severity: Moderate
Chloramphenicol and Naldemedine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may increase naldemedine concentrations, which could increase gastrointestinal effects such as abdominal pain and diarrhea or opioid withdrawal-type symptoms.
What this interaction means in plain words
Chloramphenicol and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP3A4 reduces naldemedine metabolism.
What to do
Monitor for gastrointestinal adverse effects and opioid withdrawal symptoms. Reduce or stop naldemedine if they emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Chloramphenicol with Naldemedine?
MediHelp rates the interaction as moderate. Chloramphenicol and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may increase naldemedine concentrations, which could increase gastrointestinal effects such as abdominal pain and diarrhea or opioid withdrawal-type symptoms.
How serious is the interaction between Chloramphenicol and Naldemedine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects and opioid withdrawal symptoms. Reduce or stop naldemedine if they emerge.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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