Drug interactions
Chloramphenicol + Naloxegol
Severity: Major
Chloramphenicol and Naloxegol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may increase naloxegol exposure via CYP3A4 inhibition, increasing the chance of opioid withdrawal symptoms and abdominal adverse effects. Naloxegol is contraindicated with strong CYP3A4 inhibitors, and chloramphenicol's inhibition is less well defined.
What this interaction means in plain words
Chloramphenicol and Naloxegol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
CYP3A4 inhibition reduces naloxegol metabolism.
What to do
Avoid the combination or withhold naloxegol during chloramphenicol therapy; monitor for withdrawal symptoms if used.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Chloramphenicol with Naloxegol?
MediHelp rates the interaction as major. Chloramphenicol and Naloxegol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol may increase naloxegol exposure via CYP3A4 inhibition, increasing the chance of opioid withdrawal symptoms and abdominal adverse effects. Naloxegol is contraindicated with strong CYP3A4 inhibitors, and chloramphenicol's inhibition is less well defined.
How serious is the interaction between Chloramphenicol and Naloxegol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or withhold naloxegol during chloramphenicol therapy; monitor for withdrawal symptoms if used.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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