Drug interactions
Chloramphenicol + Oliceridine
Severity: Moderate
Chloramphenicol and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and increase oliceridine exposure. This raises the risk of respiratory depression and sedation, and stopping chloramphenicol later could reduce opioid effect.
What this interaction means in plain words
Chloramphenicol and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Oliceridine belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated oliceridine metabolism by chloramphenicol.
What to do
Monitor for respiratory depression and sedation and lengthen dosing intervals or lower doses as needed. Reassess analgesia and watch for withdrawal if chloramphenicol is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Chloramphenicol with Oliceridine?
MediHelp rates the interaction as moderate. Chloramphenicol and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP3A4 and increase oliceridine exposure. This raises the risk of respiratory depression and sedation, and stopping chloramphenicol later could reduce opioid effect.
How serious is the interaction between Chloramphenicol and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for respiratory depression and sedation and lengthen dosing intervals or lower doses as needed. Reassess analgesia and watch for withdrawal if chloramphenicol is stopped.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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