Drug interactions
Chloramphenicol + Pemigatinib
Severity: Major
Chloramphenicol and Pemigatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemigatinib is metabolized by CYP3A4, so chloramphenicol may increase its exposure. This may worsen toxicities such as hyperphosphatemia, ocular effects and fatigue.
What this interaction means in plain words
Chloramphenicol and Pemigatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Pemigatinib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4, decreasing pemigatinib clearance.
What to do
Use an alternative antibiotic. If unavoidable, reduce the pemigatinib dose as per labeling for CYP3A4 inhibitors and monitor for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Pemigatinib
Frequently asked questions
Can I take Chloramphenicol with Pemigatinib?
MediHelp rates the interaction as major. Chloramphenicol and Pemigatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pemigatinib is metabolized by CYP3A4, so chloramphenicol may increase its exposure. This may worsen toxicities such as hyperphosphatemia, ocular effects and fatigue.
How serious is the interaction between Chloramphenicol and Pemigatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic. If unavoidable, reduce the pemigatinib dose as per labeling for CYP3A4 inhibitors and monitor for adverse effects.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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