Drug interactions
Chloramphenicol + Quizartinib
Severity: Major
Chloramphenicol and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may raise quizartinib exposure via CYP3A4 inhibition. Quizartinib prolongs the QT interval, so increased levels raise the risk of torsades de pointes.
What this interaction means in plain words
Chloramphenicol and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Quizartinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated quizartinib metabolism by chloramphenicol, increasing QT-prolonging exposure.
What to do
Reduce the quizartinib dose according to labeling for strong CYP3A inhibitors, or choose an alternative antibiotic. Monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Chloramphenicol with Quizartinib?
MediHelp rates the interaction as major. Chloramphenicol and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol may raise quizartinib exposure via CYP3A4 inhibition. Quizartinib prolongs the QT interval, so increased levels raise the risk of torsades de pointes.
How serious is the interaction between Chloramphenicol and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the quizartinib dose according to labeling for strong CYP3A inhibitors, or choose an alternative antibiotic. Monitor ECG and electrolytes.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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