Drug interactions
Chloramphenicol + Sparsentan
Severity: Major
Chloramphenicol and Sparsentan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is metabolized by CYP3A4, so chloramphenicol may increase its exposure. This may heighten risks of hepatotoxicity, hypotension and fluid retention.
What this interaction means in plain words
Chloramphenicol and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Sparsentan belongs to Genitourinary.
Why it happens
Chloramphenicol inhibits CYP3A4, decreasing sparsentan clearance.
What to do
Prefer an alternative antibiotic. If unavoidable, interrupt sparsentan during chloramphenicol use, then resume with titration, and monitor liver tests and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Sparsentan?
MediHelp rates the interaction as major. Chloramphenicol and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sparsentan is metabolized by CYP3A4, so chloramphenicol may increase its exposure. This may heighten risks of hepatotoxicity, hypotension and fluid retention.
How serious is the interaction between Chloramphenicol and Sparsentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic. If unavoidable, interrupt sparsentan during chloramphenicol use, then resume with titration, and monitor liver tests and blood pressure.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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